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1228569-07-0

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1228569-07-0 Usage

Description

(S)-8-(trifluoromethyl)chroman-4-amine is a chemical compound belonging to the chroman-4-amine family, characterized by a molecular formula of C10H10F3NO. It features a trifluoromethyl group at the eighth position and an amine group at the fourth position on the chroman ring. (S)-8-(trifluoromethyl)chroman-4-amine is known for its potential pharmacological activities and is of interest in medicinal chemistry and drug development due to the beneficial effects of fluorine substitution on biological activity and metabolic stability.

Uses

Used in Pharmaceutical Industry:
(S)-8-(trifluoromethyl)chroman-4-amine is used as a promising candidate for drug development and medicinal chemistry research. The presence of the trifluoromethyl group is expected to enhance the biological activity and metabolic stability of the compound, making it a valuable asset in the creation of new pharmaceuticals.
The specific applications and biological activities of (S)-8-(trifluoromethyl)chroman-4-amine are still under investigation, but its unique structure and properties suggest it may have a range of uses in the development of therapeutic agents. Further research is required to fully determine its potential applications and benefits in the pharmaceutical field.

Check Digit Verification of cas no

The CAS Registry Mumber 1228569-07-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,5,6 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1228569-07:
(9*1)+(8*2)+(7*2)+(6*8)+(5*5)+(4*6)+(3*9)+(2*0)+(1*7)=170
170 % 10 = 0
So 1228569-07-0 is a valid CAS Registry Number.

1228569-07-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (4S)-8-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-amine

1.2 Other means of identification

Product number -
Other names (S)-8-(trifluoromethyl)chroman-4-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1228569-07-0 SDS

1228569-07-0Downstream Products

1228569-07-0Relevant articles and documents

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists

Schmidt, Robert G.,Bayburt, Erol K.,Latshaw, Steven P.,Koenig, John R.,Daanen, Jerome F.,McDonald, Heath A.,Bianchi, Bruce R.,Zhong, Chengmin,Joshi, Shailen,Honore, Prisca,Marsh, Kennan C.,Lee, Chih-Hung,Faltynek, Connie R.,Gomtsyan, Arthur

, p. 1338 - 1341 (2011/04/23)

Novel chroman and tetrahydroquinoline ureas were synthesized and evaluated for their activity as TRPV1 antagonists. It was found that aryl substituents on the 7- or 8-position of both bicyclic scaffolds imparted the best in vitro potency at TRPV1. The most potent chroman ureas were assessed in chronic and acute pain models, and compounds with the ability to cross the blood-brain barrier were shown to be highly efficacious. The tetrahydroquinoline ureas were found to be potent CYP3A4 inhibitors, but replacement of bulky substituents at the nitrogen atom of the tetrahydroisoquinoline moiety with small groups such as methyl can minimize the inhibition.

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