1228569-48-9

Upstream product

• 1228569-62-7 methyl (5Z,8S)-8-hydroxy-9-(p-methoxybenzyloxy)non-5-enoate 
• 885481-78-7 methyl (5Z,8S)-8,9-dihydroxynon-5-enoate 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 
• 1228569-45-6 methyl (Z)-7-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]hept-5-enoate 
• 1228569-47-8 (5Z,8S)-8-hydroxy-9-(p-methoxybenzyloxy)non-5-enoic acid 

Relevant academic research and scientific papers

Determination of the absolute configuration of marine oxylipin topsentolide A1 by the synthesis of the enantiomer of the natural product

Two possible stereoisomers of topsentolide A1, a cytotoxic oxylipin against human solid tumor cell lines, were prepared in order to determine the stereochemistry of natural product. That is, the enantiomer of topsentolide A1, (8S,11S,12R)-isomer, and its diastereomer was efficiently synthesized in a stereoselective manner. The stereochemistry of topsentolide A1 was determined to be 8R,11R,12S by comparing NMR spectra and specific rotations of the synthetic isomers and the natural product.

Synthesis of marine oxylipin topsentolide A1 and its stereoisomers, and determination of the absolute configuration of the natural product

Four possible stereoisomers of topsentolide A1, a cytotoxic oxylipin against human solid tumor cell lines, were efficiently synthesized in a stereoselective manner in order to determine the stereochemistry of natural product. The absolute confi