1228581-03-0Relevant academic research and scientific papers
Fragment-based Differential Targeting of PPI Stabilizer Interfaces
Guillory, Xavier,Wolter, Madita,Leysen, Seppe,Neves, Joa? Filipe,Kuusk, Ave,Genet, Sylvia,Somsen, Bente,Morrow, John Kenneth,Rivers, Emma,Van Beek, Lotte,Patel, Joe,Goodnow, Robert,Schoenherr, Heike,Fuller, Nathan,Cao, Qing,Doveston, Richard G.,Brunsveld, Luc,Arkin, Michelle R.,Castaldi, Paola,Boyd, Helen,Landrieu, Isabelle,Chen, Hongming,Ottmann, Christian
, p. 6694 - 6707 (2020)
Stabilization of protein-protein interactions (PPIs) holds great potential for therapeutic agents, as illustrated by the successful drugs rapamycin and lenalidomide. However, how such interface-binding molecules can be created in a rational, bottom-up man
In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides
Milner, Phillip J.,Yang, Yang,Buchwald, Stephen L.
, p. 4775 - 4780 (2015/10/28)
A thorough investigation of the challenging Pd-catalyzed fluorination of five-membered heteroaryl bromides is presented. Crystallographic studies and density functional theory (DFT) calculations suggest that the challenging step of this transformation is
2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF
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Page/Page column 23, (2011/09/12)
[Object] Provided is a compound which has an excellent S1P1 agonist action, and is useful particularly as an active ingredient for an agent for preventing and/or treating a disease induced by undesirable lymphocyte infiltration or a disease ind
