1228630-89-4

Basic information

• Product Name: tert-butyl 4-nitropiperidine-1-carboxylate
• Synonyms: tert-butyl 4-nitropiperidine-1-carboxylate;4-Nitro-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1228630-89-4
• Molecular Formula: C₁₀H₁₈N₂O₄
• Molecular Weight: 230
• Mol File: 1228630-89-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 327.7±31.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• PKA: 7.79±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 4-nitropiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-nitropiperidine-1-carboxylate(1228630-89-4)
• EPA Substance Registry System: tert-butyl 4-nitropiperidine-1-carboxylate(1228630-89-4)

Safety Data

• Hazardous Substances Data: 1228630-89-4(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-nitropiperidine-1-carboxylate is a chemical compound with the molecular formula C11H18N2O4. It is an ester formed from tert-butanol and 4-nitropiperidine-1-carboxylic acid. tert-butyl 4-nitropiperidine-1-carboxylate is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It has a nitro functional group, which makes it useful in the development of drugs and other biologically active molecules. Tert-butyl 4-nitropiperidine-1-carboxylate is also known for its high stability and low reactivity, making it a valuable intermediate in organic synthesis. Its versatile properties and applications make it an important compound in the field of medicinal and organic chemistry.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 301673-14-3 tert-butyl 4-iodopiperidine-1-carboxylate 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 150008-24-5 tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate 

Relevant articles and documents

INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION

Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.

Copper-Catalyzed Propargylation of Nitroalkanes

Using a commercially available, inexpensive, and abundant copper catalyst system, an efficient α-functionalization of nitroalkanes with propargyl bromides is now established. This mild and robust method is highly functional group tolerant and provides straightforward access to complex secondary and tertiary homopropargylic nitroalkanes. Moreover, the utility of these α-propargylated nitroalkanes is demonstrated through downstream functionalization to biologically relevant, five-membered N-heterocycles such as pyrroles and 2-pyrrolines.

A tert-butoxy carbonyl N - -4 - nitro-piperidine preparation method

The invention relates to a preparing method of N-t-butyloxycarboryl-4-nitro piperidine. The method mainly solves the technical problems that in an existing synthetic process, the route is long, yield is low, reaction is not easy to control, experimental operation is inconvenient, and the like. According to the method, N-t-butyloxycarboryl-4-hydroxy piperidine is used as raw material to prepare N-t-butyloxycarboryl-4-iodine piperidine, and further the target product is obtained through the substitution reaction. The N-t-butyloxycarboryl-4-nitro piperidine obtained with the method is a useful intermediate or product used for synthesis of various kinds of drugs.