1228630-89-4

Usage

Uses

Used in Pharmaceutical Synthesis:
Tert-butyl 4-nitropiperidine-1-carboxylate is used as a building block for the synthesis of various pharmaceuticals. Its presence in the molecular structure allows for the development of drugs with specific therapeutic properties, making it an essential component in the creation of novel medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, tert-butyl 4-nitropiperidine-1-carboxylate is utilized as a key intermediate in the synthesis of various agrochemicals. Its role in the production of these compounds contributes to the development of effective solutions for agricultural applications, such as pest control and crop protection.
Used in Organic Chemistry Research:
Tert-butyl 4-nitropiperidine-1-carboxylate is employed as a versatile intermediate in organic chemistry research. Its unique properties and reactivity make it suitable for exploring new reaction pathways and developing innovative synthetic methods, further expanding the horizons of organic chemistry.
Used in the Synthesis of Biologically Active Molecules:
Due to its nitro functional group, tert-butyl 4-nitropiperidine-1-carboxylate is used as a precursor in the synthesis of biologically active molecules. This allows for the creation of compounds with potential applications in various biological and medicinal fields, contributing to advancements in drug discovery and development.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 301673-14-3 tert-butyl 4-iodopiperidine-1-carboxylate 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 150008-24-5 tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Enantioselective Iridium-Catalyzed Allylation of Nitroalkanes: Entry to β-Stereogenic α-Quaternary Primary Amines

The first systematic study of simple nitronate nucleophiles in iridium-catalyzed allylic alkylation is described. Using a tol-BINAP-modified π-allyliridiumC,O-benzoate catalyst, α,α-disubstituted nitronates substitute racemic branched alkyl-substituted al

INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION

Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.

Copper-Catalyzed Propargylation of Nitroalkanes

Using a commercially available, inexpensive, and abundant copper catalyst system, an efficient α-functionalization of nitroalkanes with propargyl bromides is now established. This mild and robust method is highly functional group tolerant and provides straightforward access to complex secondary and tertiary homopropargylic nitroalkanes. Moreover, the utility of these α-propargylated nitroalkanes is demonstrated through downstream functionalization to biologically relevant, five-membered N-heterocycles such as pyrroles and 2-pyrrolines.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

A tert-butoxy carbonyl N - -4 - nitro-piperidine preparation method

The invention relates to a preparing method of N-t-butyloxycarboryl-4-nitro piperidine. The method mainly solves the technical problems that in an existing synthetic process, the route is long, yield is low, reaction is not easy to control, experimental operation is inconvenient, and the like. According to the method, N-t-butyloxycarboryl-4-hydroxy piperidine is used as raw material to prepare N-t-butyloxycarboryl-4-iodine piperidine, and further the target product is obtained through the substitution reaction. The N-t-butyloxycarboryl-4-nitro piperidine obtained with the method is a useful intermediate or product used for synthesis of various kinds of drugs.

N-Boc 4-nitropiperidine: preparation and conversion into a spiropiperidine analogue of the eastern part of maraviroc

Previously unreported N-Boc 4-nitropiperidine was prepared in two steps from N-Boc-piperidone. The synthetic utility of this new intermediate was demonstrated by the development of a new and simple route to spirolactam piperidines. Further synthetic work involving a challenging triazole cyclisation allowed the preparation of a spiropiperidine analogue of the eastern part of maraviroc.