1228668-15-2

Upstream product

• 1228669-51-9 tert-butyl (S)-2-(5-(pyridin-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 1228669-50-8 1-(tert-butyl) 2-(2-oxo-2-(pyridin-4-yl)ethyl) (S)-pyrrolidine-1,2-dicarboxylate 
• 40706-98-7 3,4-difluorophenacyl bromide 
• 369-33-5 3',4'-difluoroacetophenone 
• 50890-96-5 (2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid 

Relevant academic research and scientific papers

Discovery of functionalized bisimidazoles bearing cyclic aliphatic-phenyl motifs as HCV NS5A inhibitors

This Letter describes the discovery of a number of functionalized bisimidazoles bearing a cyclohexylphenyl, piperidylphenyl, or bicyclo[2,2,2]octylphenyl motif as HCV NS5A inhibitors. Compounds 2c, 4b and 6 have demonstrated low single-digit nM potency in gt-1a replicon and double-digit pM potency in gt-1b replicon, respectively. Moreover, both 4b and 6 have, respectively, exhibited good oral bioavailability in rats with a favorable liver/plasma ratio of the drug concentration.