1228673-76-4

Upstream product

• 1146415-33-9 (2S,3'S)-2-methyl[1,3']bipyrrolidinyl dihydrochloride 
• 1228674-31-4 2-(4-bromo-2-methyl-phenyl)-8-oxa-2-aza-spiro[4.5]decan-1-one 
• 1228674-44-9 4-{2-[2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamino]-ethyl}-tetrahydro-pyran-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF

The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I) Wherein R1, R2, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor.