1228686-22-3Relevant academic research and scientific papers
Fe-catalyzed thioesterification of carboxylic esters
Magens, Silja,Plietker, Bernd
supporting information; experimental part, p. 8807 - 8809 (2011/09/16)
Second nature: Starting from shelf-stable aryl esters and thiols, a variety of carboxylic acid esters were transformed into the corresponding thioesters with no racemization of labile stereocenters (see scheme). The method was successfully applied in a native chemical-ligation-type peptide formation, which suggests that the thiol may act as a co-catalyst for future 1,2-additions of pronucleophiles to carboxylic esters.
Nucleophilic iron catalysis in transesterifications: Scope and limitations
Magens, Silja,Plietker, Bernd
supporting information; experimental part, p. 3715 - 3721 (2010/08/07)
Figure presented The ester bond is one of the most common structural motifs found in nature. Apart from the condensation between an acid and an alcohol, transesterifications represent another mechanistic alternative for the preparation of this compound class. The present paper summarizes our most recent investigations in this field, using nucleophilic iron complexes as catalysts for transesterifications under neutral conditions. This new type of metal catalyst complements the existing methodologies, which rely on Lewis acidic metal complexes. Investigations on scope and limitations, stereochemical course, and chemoselectivities will be presented.
