1228694-07-2

Upstream product

• 4382-54-1 5-methoxy-1H-indole-2-carboxylic acid 
• 919535-18-5 3,6-di-tert-butyl 7-methyl (S)-1-(chloromethyl)-5-hydroxy-1,2-dihydropyrrolo[3,2-e]indole-3,6,7-tricarboxylate 
• 736138-02-6 methyl 5-(benzyloxy)-3,6-bis(tert-butyloxycarbonyl)-(1S)-(chloromethyl)-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate 
• 881422-32-8 3-(benzyloxy)-5-nitrobenzaldehyde 
• 919535-06-1 1-(1,1-dimethylethyl)-2-methyl 5-[[(1,1-dimethylethoxy)-carbonyl]amino]-4-iodo-7-(phenylmethoxy)indole-1,2-dicarboxylate 
• 539856-50-3 methyl 7-(benzyloxy)-1-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]indole-2-carboxylate 
• 539856-43-4 methyl 5-amino-7-(benzyloxy)-1-(tert-butoxycarbonyl)indole-2-carboxylate 
• 539856-49-0 1-(1,1-dimethylethyl)-2-methyl-5-nitro-6-(phenylmethoxy)-indole-1,2-dicarboxylate 
• 71022-43-0 3,5-dinitrobenzyl alcohol 

Relevant academic research and scientific papers

SECO-CYCLOPROPAPYRROLOINDOLE COMPOUNDS, ANTIBODY-DRUG CONJUGATES THEREOF, AND METHODS OF MAKING AND USE

seco-Cyclopropapyrroloindole compounds of formula (I) where Hal, R1, R2, and R3 are as defined in the application, are potent anti-cancer agents that can be used in antibody-drug conjugates.

Synthesis and evaluation of a series of C5′-substituted duocarmycin SA analogs

The synthesis and evaluation of a key series of analogs of duocarmycin SA, bearing a single substituent at the C5′ position of the DNA binding subunit, are described.