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1228699-85-1

dimethyl (1-(2-fluorophenyl)-1-hydroxyethyl)phosphonate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1228699-85-1 Structure

  • Basic information

    1. Product Name: dimethyl (1-(2-fluorophenyl)-1-hydroxyethyl)phosphonate
    2. Synonyms: dimethyl (1-(2-fluorophenyl)-1-hydroxyethyl)phosphonate
    3. CAS NO:1228699-85-1
    4. Molecular Formula:
    5. Molecular Weight: 248.191
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1228699-85-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: dimethyl (1-(2-fluorophenyl)-1-hydroxyethyl)phosphonate(CAS DataBase Reference)
    10. NIST Chemistry Reference: dimethyl (1-(2-fluorophenyl)-1-hydroxyethyl)phosphonate(1228699-85-1)
    11. EPA Substance Registry System: dimethyl (1-(2-fluorophenyl)-1-hydroxyethyl)phosphonate(1228699-85-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1228699-85-1(Hazardous Substances Data)

1228699-85-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1228699-85-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,6,9 and 9 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1228699-85:
(9*1)+(8*2)+(7*2)+(6*8)+(5*6)+(4*9)+(3*9)+(2*8)+(1*5)=201
201 % 10 = 1
So 1228699-85-1 is a valid CAS Registry Number.

1228699-85-1Downstream Products

1228699-85-1Relevant articles and documents

Solvent-free synthesis of Tertiaryα-Hydroxyphosphates by the Triethylamine-catalyzed hydrophosphonylation of ketones

Wang, Chubei,Zhou, Jianwei,Lv, Xingbin,Wen, Junlei,He, Hongwu

, p. 1334 - 1339 (2013)

A new, environmentally benign, convenient, and easy method of synthesizing tertiary α-hydroxyphosphonates by the triethylamine-catalyzed hydrophosphonylation of unactivated ketones was developed. In the presence of triethylamine, aromatic or heteroaromati

Synthesis and anticancer cytotoxicity with structural context of an α-hydroxyphosphonate based compound library derived from substituted benzaldehydes

Rádai, Zita,Windt, Tímea,Nagy, Veronika,Füredi, András,Kiss, Nóra Zsuzsa,Ranelovi?, Ivan,Tóvári, József,Keglevich, Gy?rgy,Szakács, Gergely,Tóth, Szilárd

supporting information, p. 14028 - 14035 (2019/09/18)

We synthesized substituted benzaldehyde derived α-hydroxyphosphonates (αOHP), α-hydroxyphosphonic acids (αOHPA) and α-phosphinoyloxyphosphonates (αOPP) and characterized their cytotoxicity against a panel of cancer cell lines. A library containing 56 analogues was screened against Mes-Sa parental and Mes-Sa/Dx5 multidrug resistant uterine sarcoma cell lines, using a fluorescence-based cytotoxicity assay. The cytotoxicity screening revealed that dibenzyl-αOHPs and dimethyl-α-diphenyl-OPPs were the most active clusters, which encouraged us to synthesize further dibenzyl-α-diphenyl-OPP derivatives that elicited pronounced cell killing. Further structure-activity relationships showed the relevance of hydrophobicity and the position of substituents on the main benzene ring as determinants of toxicity. The most active analogs proved to be equally, or even more toxic to the multidrug resistant (MDR) cell line Mes-Sa/Dx5, suggesting these compounds may overcome P-glycoprotein mediated multidrug resistance by evading the drug transporter.

Highly efficient synthesis of quaternary α-hydroxy phosphonates via lewis acid-catalyzed hydrophosphonylation of ketones

Zhou, Xin,Liu, Yanling,Chang, Lu,Zhao, Jiannan,Shang, Deju,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming

supporting information; experimental part, p. 2567 - 2572 (2009/12/27)

A Lewis acid catalyst has been first applied to the hydrophosphonylation of ketones, giving the corresponding quaternary a-hydroxy phosphonates in high yields (up to 98%). The present method was highly tolerable for functionalized ketones. Moreover, the f

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