122872-34-8Relevant academic research and scientific papers
Asymmetric Syntheses of Chiral Propane-1,3-diols Starting from Malonic Acid
Ihara, Masataka,Takahashi, Masanobu,Taniguchi, Nobuaki,Yasui, Ken,Fukumoto, Keiichiro,Kametani, Tetsuji
, p. 897 - 903 (2007/10/02)
Syntheses of chiral intermediates having one tertiary asymmetric centre were carried out via chiral half-esters of monoalkylmalonic acids.The menthyl half-ester of ethylmalonic acid afforded a single diastereoisomer through crystallisation-induced asymmetric transformation (second-order asymmertic transformation).Furthermore enantioselective preparation of unsymmertical propane-1,3-diol derivatives was achieved by the use of 8-phenylmenthyl half-esters.
