122875-17-6

Basic information

• Product Name: 4-(5-Oxo-cyclohex-1-enyl)-butyramide
• CAS NO: 122875-17-6
• Molecular Weight: 181.235
• Mol File: 122875-17-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(5-Oxo-cyclohex-1-enyl)-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-Oxo-cyclohex-1-enyl)-butyramide(122875-17-6)
• EPA Substance Registry System: 4-(5-Oxo-cyclohex-1-enyl)-butyramide(122875-17-6)

Safety Data

• Hazardous Substances Data: 122875-17-6(Hazardous Substances Data)

Upstream product

• 122875-16-5 4-(5-Methoxy-cyclohexa-1,4-dienyl)-butyramide 

Relevant articles and documents

Studies on the Synthesis of 1-Azaspiroundecanes Related to Histrionicotoxin

3-Methoxybenzaldehyde was converted into 4-(3-methoxyphenyl)butylamine (4), and the derived hydrochloride was reduced with Li/NH3/EtOH to give the spirocyclic keto amine 6.The reduction of 6 and urethane derivatives 13 and 14 to give the corresponding cis and trans alcohols 9/10, 15/16, and 17/18 was studied.The keto amine 6 upon attempted ketalization underwent rearrangement to give the α,β-unsaturated imine 11.Treatment of 6 with N-chlorosuccinimide, followed by DBU, gave the aziridine 21.The amide 25 was converted derectly into 1-azaspiroundecane-2,8-dione (24) by Birch reduction and acid hydrolysis.The dione 24 underwent stereospecific reduction with LS-Selectride to give the cis alcohol 30.