1228758-53-9Relevant academic research and scientific papers
Copper catalyzed asymmetric propargylation of aldehydes
Fandrick, Daniel R.,Fandrick, Keith R.,Reeves, Jonathan T.,Tan, Zhulin,Tang, Wenjun,Capacci, Andrew G.,Rodriguez, Sonia,Song, Jinhua J.,Lee, Heewon,Yee, Nathan K.,Senanayake, Chris H.
supporting information; experimental part, p. 7600 - 7601 (2010/07/08)
The highly enantio- and regioselective copper catalyzed asymmetric propargylation of aldehydes with a propargyl borolane reagent is reported. The methodology demonstrated broad functional group tolerance and provided high enantioselectivities for aliphatic, vinyl, and aryl aldehydes. The utility of the TMS homopropargylic alcohols was demonstrated by the facile conversion to a chiral dihydropyranone.
