122876-62-4Relevant academic research and scientific papers
Latrunculin-Based Macrolides and Their Uses
-
, (2011/06/24)
Latrunculin derivatives are disclosed, as are anti-invasive and cytotoxic uses for latrunculins and latrunculin derivatives, and semisyntheses of latrunculin derivatives. The latrunculins and latrunculin derivatives are useful, for example, in treating cancers.
On the Chemistry of Latrunculins A and B
Blasberger, Dina,Carmely, Shmuel,Cojocaru, Miriam,Spector, Ilan,Shochet, Nava R.,Kashman, Yoel
, p. 1171 - 1188 (2007/10/02)
The chemical behavior of latrunculins A (1) and (B) (Lat A and B) under a variety of reaction conditions is described.The combination of the macrolide, the THP-lactol, and the 2-thiazolidinone rings was found to result on interesting unpredicted chemical transformations.The structures of two new Lats, 6,7-epoxy-Lat A (3) and Lat M (4) isolated from Latrunculia magnifica, are discussed.
