1228773-89-4

Upstream product

• 624-31-7 4-tolyl iodide 
• 1228773-88-3 (R)-tert-butyl 2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetate 
• 1228774-07-9 (R)-tert-butyl 2-hydroxy-2-((R)-3-oxomorpholin-2-yl)acetate 

Downstream Products

• 1269523-34-3 5-cyano-2-((R)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamido)benzamide 
• 1269523-35-4 2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carbonitrile 
• 1616070-41-7 2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile 
• 1616070-42-8 ethyl 2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-1H-benzo[d]imidazole-6-carbimidate 
• 1616068-86-0 2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-1H-benzo[d]imidazole-6-carboximidamide 
• 1269523-33-2 2-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4-oxo-1,4-dihydroquinazoline-6-carboximidamide 
• 1269523-38-7 3-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4H-benzo[e][1,2,4]thiadiazine-7-carbonitrile 1,1-dioxide 
• 1616070-43-9 ethyl 3-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4H-benzo[e][1,2,4]thiadiazine-7-carbimidate 1,1-dioxide 
• 1269523-36-5 3-((S)-hydroxy((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)methyl)-4H-benzo[e][1,2,4]thiadiazine-7-carboximidamide 1,1-dioxide 
• 1616070-40-6 (R)-N-(2-amino-5-cyanophenyl)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamide 
• 1269523-37-6 (R)-N-(4-cyano-2-sulfamoylphenyl)-2-hydroxy-2-((R)-3-oxo-4-(p-tolyl)morpholin-2-yl)acetamide 

Relevant academic research and scientific papers

FACTOR IXa INHIBITORS

The present invention provides a compound of Formula (I) wherein A is a heterocycle ring system and B is a heterocycle ring system or aryl ring system, and pharmaceutical compositions comprising one or more of said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.

MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS

The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods fo