1228827-77-7

Basic information

• Product Name: benzyl 6-(benzyloxy)-1,2,3,4-tetrahydrocarbazol-3-ylcarbamate
• Synonyms: benzyl 6-(benzyloxy)-1,2,3,4-tetrahydrocarbazol-3-ylcarbamate
• CAS NO: 1228827-77-7
• Molecular Weight: 426.515
• Mol File: 1228827-77-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl 6-(benzyloxy)-1,2,3,4-tetrahydrocarbazol-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 6-(benzyloxy)-1,2,3,4-tetrahydrocarbazol-3-ylcarbamate(1228827-77-7)
• EPA Substance Registry System: benzyl 6-(benzyloxy)-1,2,3,4-tetrahydrocarbazol-3-ylcarbamate(1228827-77-7)

Safety Data

• Hazardous Substances Data: 1228827-77-7(Hazardous Substances Data)

Upstream product

• 16801-63-1 benzyl N-(4-oxocyclohexyl)carbamate 
• 52068-30-1 4-benzyloxyphenylhydrazine hydrochloride 

Relevant articles and documents

Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors

The discovery of new templates and their subsequent elaboration to clinically useful receptor tyrosine kinase (RTK) inhibitors continues to be an important issue. RTKs are a class of enzymes responsible for the activation of different cellular signal transduction cascades. The majority of the known small molecules RTK inhibitors are ATP-competitive and they are multiple targeted inhibitors. We describe here serotonin derivatives as a new class of multiple targeted RTK inhibitors. In contrast to most other RTK inhibitors they act via a non-ATP-competitive (allosteric) mechanism. Furthermore, they are able to inhibit the proliferation of HUVE cells, fibroblasts and two cancer cell lines.