1228877-08-4Relevant academic research and scientific papers
Chemoenzymatic dynamic kinetic resolution of axially chiral alienes
B?ckvall, Jan-E.,Deska, Jan,Del Pozo Ochoa, Carolina
, p. 4447 - 4451 (2010)
(Chemical Equation Presented) At the palladium: Dimeric palladium bromide complexes bearing monodentate N-heterocyclic carbene ligands have been identified as efficient catalysts for the chemoselective racemization of axially chiral allenyl alcohols. In combination with porcine pancreatic lipase as biocatalyst, a dynamic kinetic resolution has been developed, giving access to optically active alienes in good yield and high enantiomeric purity (see scheme).
Enzymatic kinetic resolution of primary allenic alcohols. Application to the total synthesis and stereochemical assignment of striatisporolide A
Deska, Jan,Baeckvall, Jan-E.
scheme or table, p. 3379 - 3381 (2010/01/06)
Crude Porcine pancreatic lipase was successfully used for the kinetic resolution of axially chiral primary allenic alcohols providing very high enantioselectivities with E values above 200. This simple access to optically active allenes was applied to the total synthesis of the fungal metabolite (-)-striatisporolide A, allowing its unambiguous stereochemical assignment.
