1228931-47-2Relevant academic research and scientific papers
A preparative synthesis of human chitinase fluorogenic substrate (4' -deoxychitobiosyl)-4-methylumbelliferone
Dinkelaar, Jasper,Duivenvoorden, Boudewijn A.,Wennekes, Tom,Overkleeft, Herman S.,Boot, Rolf G.,Aerts, Johannes M. F. G.,Codee, Jeroen D. C.,Van Der Marel, Gijs A.
, p. 2565 - 2570 (2010)
To meet the increasing clinical demand for the diagnostic agent (4′-deoxychitobiosyl)-4-methylumbelliferone, a flexible and scalable route of synthesis is needed. In this paper such a route is presented. The key to the route is the use of a partially protected thiophenyl glucosamine as starting material for the preparation of both the reducing and nonreducing end building blocks of the 4′-deoxychitobiose disaccharide.
