1228931-89-2

Upstream product

• 1228931-76-7 methyl 5-(4-chlorophenyl)-3-hydroxy-2-methylene-pent-4-ynoate 
• 108-24-7 acetic anhydride 
• 67228-76-6 4-chlorophenylpropynal 

Downstream Products

• 1228932-03-3 (E)-methyl 2-(azidomethyl)-5-(4-chlorophenyl)pent-2-en-4-ynoate 
• 1443359-76-9 methyl 5-(4-chlorobenzyl)thiophene-3-carboxylate 
• 1569083-34-6 methyl 5-(4-chlorobenzyl)furan-3-carboxylate 
• 1618099-03-8 methyl 4-(4-chlorobenzyl)-2-naphthoate 

Relevant academic research and scientific papers

Copper-Catalyzed Intramolecular Chalcogenoamination of Enynyl Azides: Synthesis of 5-Selenyl/Sulfenyl Nicotinates

A novel methodology for the synthesis of 5-selenyl/sulfenyl nicotinates involving copper-catalyzed organochalcogenyl aza-annulation of enynyl azide with diorganyl-dichalcogenides has been described. This method offers difunctionalization of alkynes via regioselective intramolecular chalcogenoamination in one pot to provide substituted 5-chalcogenyl nicotinates in good to excellent yields. The resulting nicotinates provide access to their oxides, sulfones, and acid derivatives.

Cu(I)-Catalyzed Aminative Aza-Annulation of Enynyl Azide using N-Fluorobenzenesulfonimide: Synthesis of 5-Aminonicotinates

An unprecedented copper-catalyzed aminative aza-annulation of enynyl azide using commercially available N-fluorobenzenesulfonimide (NFSI) as an amination reagent is described. The reaction proceeds via regioselective inter-/intramolecular diamination, incorporating one nitrogen from the NFSI and the other from the azide, to provide amino-substituted nicotinate derivatives in a single step with moderate to high yield. This method represents an efficient way to access diverse aminonicotinates through direct C-N bond-coupling processes.

3,5-Disubstituted 6H-pyrrolo[1,2-c][1,2,3]triazoles from Morita-Baylis-Hillman adducts of propargyl aldehydes

A simple method for synthesizing several 6H-pyrrolo[1,2-c][1,2,3]triazole derivatives having a methoxycarbonyl or an acetyl group at C-5 position and 7,8-dihydro-4H-[1,2,3]triazolo[1,5-a]indol-5(6H)-ones via an intramolecular 1,3-dipolar cycloaddition reaction of azido enynes, which were readily obtained from the Morita-Baylis-Hillman acetates of propargyl aldehydes with sodium azide, has been developed.