122898-08-2Relevant articles and documents
Synthesis of 3- and 4-Substituted Cyclic α-Amino Acids Structurally Related to ACPD
Alonso, Francisco,Mico, Irene,Najera, Carmen,Sansano, Jose M.,Yus, Miguel,et al.
, p. 10259 - 10280 (2007/10/02)
The preparation of 3-substituted cyclopentanones 12-16, 4-substituted cyclohexanones 23-28 and cycloheptanones 38-41 is described.Substituents in the cycloalkanones are carboxylate, phosphonate or tetrazole groups, separated from the ring by a 0, 1, 2, or 3 carbon atoms chain.These cycloalkanones have been transformed into α-amino acids 9-11 by hydrolysis of the corresponding hydantoin derivatives 21, 37 and 62, obtained under Bucherer-Bergs reaction conditions.
NOVEL FREE RADICAL RING-EXPANSION REACTIONS
Dowd, Paul,Choi, Soo-Chang
, p. 77 - 90 (2007/10/02)
A novel free radical initiated ring expansion of haloalkyl β-keto esters is described.Following alkylation of the β-keto ester with the appropriate dihalide, the resulting halide is treated at reflux with tri-n-butyltin hydride.Rearrangement to the homolo
