122902-09-4Relevant academic research and scientific papers
Copper-Catalyzed Formal Dehydrogenative Coupling of Carbonyls with Polyfluoroarenes Leading to β-C-H Arylation
Xie, Weilong,Kim, Dongwook,Chang, Sukbok
, p. 20588 - 20593 (2020/12/23)
We herein communicate a formal dehydrogenative coupling of carbonyls with polyfluoroarenes enabled by Cu catalysis. Silyl enol ethers initially prepared from carbonyls are postulated to undergo the copper-mediated oxidative dehydrogenative coupling with polyfluoroarenes via a radical pathway. Including cyclic and linear ketones, aldehydes, and esters, a broad range of β-aryl carbonyl products were efficiently obtained in high regio- and stereoselectivity with excellent functional group tolerance.
Reversal of ?-Facial Diastereoselection upon Electronegative Substitution of the Substrate and the Reagent
Cieplak, Andrzej S.,Tait, Bradley D.,Johnson, Carl R.
, p. 8447 - 8462 (2007/10/02)
Electonegative substitution at C-3 of cyclohexanone and methylenecyclohexane is found to increase the relative proportion of axial attack in a number of reactions widely differing from the points of view of the transition-state polarization, geometry, and
