1229225-43-7

Basic information

• Product Name: Tetrahydrocinacalcet Hydrochloride
• Synonyms: (αR)-5,6,7,8-Tetrahydro-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]-1-naphthaleneMethanaMine Hydrochloride;Tetrahydro Cinacalcet Hydrochloride;Tetrahydrocinacalcet Hydrochloride;N-[(1R)-1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine:hydrochloride
• CAS NO: 1229225-43-7
• Molecular Formula: C₂₂H₂₆F₃N*ClH
• Molecular Weight: 397.9046896
• Mol File: 1229225-43-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Tetrahydrocinacalcet Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydrocinacalcet Hydrochloride(1229225-43-7)
• EPA Substance Registry System: Tetrahydrocinacalcet Hydrochloride(1229225-43-7)

Safety Data

• Hazardous Substances Data: 1229225-43-7(Hazardous Substances Data)

Usage

Uses

Tetrahydrocinacalcet is a hydrogenated impurity of Cinacalcet (C441800).

Upstream product

• 1229224-93-4 (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methane amine 

Relevant articles and documents

HIGHLY PURE CINACALCET OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Provided herein are impurities of cinacalcet, (R)-α-methyl-N-[3-[3-(trifluoromethyl) phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methaneamine (tetrahydro cinacalcet impurity), (R)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1- naphthalenemethaneamine-N-oxide (cinacalcet N-oxide impurity) and (R)-α-methyl-N-[3-[3- (trifiuoromethyl)phenyl]methyl]-1-naphthalenemethaneamine (benzylamine impurity); and processes for preparation and isolation thereof. Provided further herein is a highly pure cinacalcet or a pharmaceutically acceptable salt thereof substantially free of impurities, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure cinacalcet or a pharmaceutically acceptable salt thereof substantially free of impurities.