1229227-01-3Relevant academic research and scientific papers
A process for preparing aldehyde group benzene boric acid
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Paragraph 0028; 0029; 0030, (2017/07/04)
The invention discloses a method for preparing formyl phenylboronic acid, which comprises the following steps: heating halogenated phenylboronic acid in toluene or heptane under reflux for dewatering to form a tripolymer, mixing the tripolymer with dimethylformamide, dropwisely adding n-butyllithium at low temperature to react by a one-pot process, hydrolyzing with hydrochloric acid, and recrystallizing to obtain the formyl phenylboronic acid. The method is simple to operate, avoids the process of separating the intermediate after formyl protection in the conventional technique, has high universality, can obtain favorable yield for ortho-, meta- and para- formyl phenylboronic acids, and is beneficial to scale-up production.
A process for preparing carboxyl boric acid
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Paragraph 0030; 0031, (2017/08/25)
The invention discloses a method for preparing carboxyl phenylboronic acid. The method comprises the following steps of starting from halogenated phenylboronic acid, heating, refluxing and dehydrating in a solvent to form a tripolymer; then forming a grignard reagent of corresponding tripolymer from tripolymer and magnesium metal or isopropyl magnesium chloride; then introducing a carbon dioxide gas at low temperature or adding dry ice for reaction; after the reaction is finished, adding hydrochloric acid, regulating till pH is equal to 2-3, and hydrolyzing; and precipitating carboxyl phenylboronic acid, filtering, and drying to obtain a pure product. The method disclosed by the invention can achieve good yield on ortho-position, meta-position and para-position carboxyl phenylboronic acid, is simple in used reagent and easy and convenient to operate and prevents the generation of a large quantity of solid wastes.
Transition-metal-free electrophilic amination of arylboroxines
Xiao, Qing,Tian, Leiming,Tan, Renchang,Xia, Ying,Qiu, Di,Zhang, Yan,Wang, Jianbo
supporting information; experimental part, p. 4230 - 4233 (2012/09/22)
A transition-metal-free strategy to construct C(sp2)-N bonds using arylboroxines and O-benzoyl hydroxylamines as coupling partners has been developed. This transformation provides a useful method to access various aromatic amines.
