1229236-36-5

Basic information

• Product Name: 1-benzyl-4-(4-chloro-3-fluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid
• Synonyms: 1-benzyl-4-(4-chloro-3-fluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid
• CAS NO: 1229236-36-5
• Molecular Weight: 331.774
• Mol File: 1229236-36-5.mol

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-(4-chloro-3-fluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(4-chloro-3-fluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid(1229236-36-5)
• EPA Substance Registry System: 1-benzyl-4-(4-chloro-3-fluoro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid(1229236-36-5)

Safety Data

• Hazardous Substances Data: 1229236-36-5(Hazardous Substances Data)

Upstream product

• 202982-67-0 1-chloro-2-fluoro-4-iodo-benzene 
• 1229236-37-6 3-(4-chloro-3-fluoro-phenyl)-propynoic acid ethyl ester 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 

Downstream Products

• 1229236-29-6 (3S,4S)-1-Benzyl-4-(4-chloro-3-fluoro-phenyl)-pyrrolidine-3-carboxylic acid 
• 1310821-85-2 [(3S,4R)-1-Benzyl-4-(4-chloro-3-fluoro-phenyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester 
• 1310821-84-1 (3S,4R)-1-Benzyl-4-(4-chloro-3-fluoro-phenyl)-pyrrolidine-3-carboxylic acid 
• 1229236-30-9 (3R,4R)-1-Benzyl-4-(4-chloro-3-fluoro-phenyl)-pyrrolidine-3-carboxylic acid 

Relevant articles and documents

PYRROLIDINE COMPOUNDS

The present application relates to compounds of formula wherein R1, R2, R3, R4, and n are defined herein or to a pharmaceutically active salt thereof. The present compounds are high potential NK-3 receptor antag

PYRROLIDINE DERIVATIVES AS NK - 3 RECEPTOR ANTAGONISTS

The present application relates to compounds of formula (I) wherein R1 is hydrogen, halogen, cyano, lower alkyl or lower alkyl substituted by halogen; n is 1, 2 or 3, if n is 2 or 3, R1 can be different; R2 is C2-7/s

PROCESS FOR THE PREPARATION OF PYROLLIDINE-3-CARBOXYLIC ACIDS

The invention relates to a novel process for the preparation of (3S,4S)- or (3R,4R)-1-benzyl-4-(halogen-aryl)-pyrrolidine-3-carboxylic acids of formula I or salts thereof, wherein X and Y are each independently hydrogen or a halogen atom, with the proviso that at least one of X or Y is a halogen atom. The compounds of formula I are useful as starting materials or intermediates for the preparation of pharmaceutically active compounds, especially for compounds, which are useful for the treatment of central nervous system disorders.