1229283-35-5Relevant academic research and scientific papers
Highly modular assembly of cationic helical scaffolds: rapid synthesis of diverse helquats via differential quaternization
Severa, Luká?,Adriaenssens, Louis,Vávra, Jan,?aman, David,Císa?ová, Ivana,Fiedler, Pavel,Teply, Filip
, p. 3537 - 3552 (2010)
A protocol for rapid and highly modular assembly of a diverse set of helquats is described. From a common bis-isoquinoline precursor, two successive distinct pyridine-type nitrogen quaternizations followed by rhodium-catalyzed [2+2+2] cycloaddition afford non-symmetric [7]helquats. This route allows for straightforward molecular editing of cationic helical skeletons as exemplified by the synthesis of 15 different [5]-, [6]-, and [7]helquats.
