122929-08-2 Usage
Uses
Used in Neurophysiological Research:
CORAZONIN is used as a research tool for understanding the neurophysiological processes and behaviors in insects, crustaceans, and ticks. Its role in controlling speciesand stage-specific functions makes it a valuable asset in studying the central nervous system and its influence on various biological processes.
Used in Pharmaceutical Development:
Given its involvement in controlling specific functions, CORAZONIN may be used as a target for the development of pharmaceuticals aimed at modulating certain behaviors or physiological processes in insects, crustaceans, and ticks. This could have applications in areas such as pest control, agriculture, and even potentially in the treatment of certain neurological disorders.
Used in Ecological and Environmental Studies:
CORAZONIN's role in controlling speciesand stage-specific functions can also be utilized in ecological and environmental studies. Understanding the neuropeptide's influence on the behavior and development of various species can provide insights into population dynamics, species interactions, and the overall health of ecosystems.
Structure
Corazonin is a very conserved N-terminally blocked undecapeptide amidated at the C-terminus. The aa sequence is conserved in all examined arthropods (insects, crustaceans, and ticks). Corazonin is distantly related to the vertebrate gonadotropinreleasing hormone (GnRH) and the GnRH-like peptide from mollusks.
Properties
Corazonin:Mr 1350–1370; soluble in water, physiological saline, and 50%–70% methanol or ethanol.
Regulation of synthesis and release
Corazonin expression appears to be constitutive. In locusts, external environmental conditions such as high population density and low temperature seem to elicit corazonin secretion from the CC.In D. melanogaster, corazonin is centrally released from the abdominal interneurons during mating.
Discovery
Corazonin was isolated as a cardioactive peptide from the corpora cardiaca (CC) of the cockroach Periplaneta americana, and subsequently identified in many arthropods. This neuropeptide controls cuticle melanization in locusts and crayfish, initiation of the ecdysis sequence in moths, and modulation of stress responses and male reproduction in flies.
Biological functions
Corazonin stimulates the heartbeat in P. americana and Rhodnius prolixus in vitro, but is inactive in vivo and in other insects.Corazonin controls eye pigment migration, melanization of the cuticle, and a shift to the gregarious phase in locusts.In the crustacean Procambarus clarkii, it regulates chromatophore migration in the integument.
Check Digit Verification of cas no
The CAS Registry Mumber 122929-08-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,9,2 and 9 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 122929-08:
(8*1)+(7*2)+(6*2)+(5*9)+(4*2)+(3*9)+(2*0)+(1*8)=122
122 % 10 = 2
So 122929-08-2 is a valid CAS Registry Number.
InChI:InChI=1/C62H84N18O18/c1-30(82)50(60(97)75-41(52(65)89)26-47(64)86)80-58(95)44(25-34-27-69-37-12-7-6-11-36(34)37)72-49(88)28-70-53(90)38(13-8-22-68-62(66)67)73-59(96)45(29-81)78-57(94)42(24-33-14-16-35(84)17-15-33)76-54(91)40(18-20-46(63)85)74-56(93)43(23-32-9-4-3-5-10-32)77-61(98)51(31(2)83)79-55(92)39-19-21-48(87)71-39/h3-7,9-12,14-17,27,30-31,38-45,50-51,69,81-84H,8,13,18-26,28-29H2,1-2H3,(H2,63,85)(H2,64,86)(H2,65,89)(H,70,90)(H,71,87)(H,72,88)(H,73,96)(H,74,93)(H,75,97)(H,76,91)(H,77,98)(H,78,94)(H,79,92)(H,80,95)(H4,66,67,68)
