1229291-51-3Relevant articles and documents
Synthesis and preliminary biological studies of 3-substituted indoles accessed by a palladium-catalyzed enantioselective alkene difunctionalization reaction
Pathak, Tejas P.,Gligorich, Keith M.,Welm, Bryan E.,Sigman, Matthew S.
supporting information; experimental part, p. 7870 - 7871 (2010/08/05)
A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.