1229313-10-3

Basic information

• Product Name: tert-butyl 4-(3-nitrobenzyloxyimino)piperidin-1-carboxylate
• Synonyms: tert-butyl 4-(3-nitrobenzyloxyimino)piperidin-1-carboxylate
• CAS NO: 1229313-10-3
• Molecular Weight: 349.387
• Mol File: 1229313-10-3.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(3-nitrobenzyloxyimino)piperidin-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(3-nitrobenzyloxyimino)piperidin-1-carboxylate(1229313-10-3)
• EPA Substance Registry System: tert-butyl 4-(3-nitrobenzyloxyimino)piperidin-1-carboxylate(1229313-10-3)

Safety Data

• Hazardous Substances Data: 1229313-10-3(Hazardous Substances Data)

Upstream product

• 150008-24-5 tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate 
• 3958-57-4 1-bromomethyl-3-nitrobenzene 

Relevant articles and documents

Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives

In an attempt to find novel azole antifungal agents with improved activity and broader spectrum, computer modeling was used to design a series of new azoles with piperidin-4-one O-substituted oxime side chains. Molecular docking studies revealed that they formed hydrophobic and hydrogen-bonding interactions with lanosterol 14α-demethylase of Candida albicans (CACYP51). In vitro antifungal assay indicates that most of the synthesized compounds showed good activity against tested fungal pathogens. In comparison with fluconazole, itraconazole and voriconazole, several compounds (such as 10c, 10e, and 10i) show more potent antifungal activity and broader spectrum, suggesting that they are promising leads for the development of novel antifungal agents.