122934-76-3

Upstream product

• 122934-75-2 4-<(1ξ,2ξ,4aS,5S,8aS)-(+)-Decahydro-1-hydroxy-2,5,8a-trimethyl-5-(4-methylpent-3-enyl)naphthalen-1-yl>butan-2-one Ethylene Acetal 
• 136598-01-1 (4aS,5S,6S,8aS)-(-)-2,4,4a,5,6,7,8,8a-Octahydro-6-hydroxy-5,8a-dimethyl-5-(prop-2-enyl)naphthalen-1(2H)-one 1-(Ethylene Acetal) 
• 122934-83-2 (+)-Methyl (2ξ,4aS,5S,8aS)-Decahydro-2,5,8a-trimethyl-5-(4-methylpent-3-enyl)-1-oxonaphthalene-2-carboxylate 
• 136598-02-2 O-<(1S,2S,4aS,8aS)-(-)-5-Ethylenedioxydecahydro-1,4a-dimethyl-1-(prop-2-enyl)naphthalen-2-yl> S-Methyl Dithiocarbonate 
• 122934-82-1 (+)-Methyl (2ξ,4aS,5S,8aS)-Decahydro-5,8a-dimethyl-5-(4-methylpent-3-enyl)-1-oxonaphthalene-2-carboxylate 
• 122934-84-3 (2ξ,4aS,5S,8aS)-(+)-3,4,4a,5,6,7,8,8a-Octahydro-2,5,8a-trimethyl-5-(4-methylpent-3-enyl)naphthalen-1(2H)-one 
• 41722-49-0 (S)-1,4a-dimethyl-4,4a,7,8-tetrahydronaphthalene-2,5(3H,6H)-dione 
• 136598-03-3 (4aS,5S,8aS)-5,8a-Dimethyl-5-(4-methyl-pent-3-enyl)-1-oxo-decahydro-naphthalene-2-carboxylic acid methyl ester 
• 136598-04-4 (4aS,5S,8aS)-2,5,8a-Trimethyl-5-(4-methyl-pent-3-enyl)-octahydro-naphthalen-1-one 
• 122934-81-0 (4aS,5S,8aS)-(+)-3,4,4a,5,6,7,8,8a-Octahydro-5,8a-dimethyl-5-(4-methylpent-3-enyl)naphthalen-1(2H)-one Ethylene Acetal 
• 122934-80-9 3-<(1S,4aS,8aS)-5-Ethylenedioxydecahydro-1,4a-dimethylnaphthalen-1-yl>propanol 
• 122934-74-1 (4aS,5S,8aS)-(-)-5β,8aβ-dimethyl-5α-(4-methyl-3-pentenyl)-3,4,4a,5,6,7,8,8a-octahydro-1(2H)-naphthalenone 
• 123001-10-5 (4aS,5S,8aS)-(-)-3,4,4a,5,6,7,8,8a-Octahydro-5,8a-dimethyl-5-(prop-2-enyl)naphthalen-1(2H)-one Ethylene Acetal 
• 122934-73-0 (4aS,5S,8aS)-(-)-3,4,4a,5,6,7,8,8a-Octahydro-5-(3-hydroxypropyl)-5,8a-dimethylnaphthalen-1(2H)-one Ethylene Acetal 

Relevant academic research and scientific papers

Total Synthesis of (+)-Dysideapalaunic Acid

The total synthesis of (+)-dysideapalaunic acid (1), a sesquiterpenic aldose reductase inhibitor, has been accomplished; the absolute stereochemistry of (1) is thus established as 4S,5S,10S.

Total Synthesis and Absolute Stereostructure of (+)-Dysideapalaunic Acid

The total synthesis of (+)-dysideapalaunic acid, a sesterterpenic aldose reductase inhibitor, has been accomplished.Starting from optically active (8aS)-(+)-3,4,8,8a-tetrahydro-5,8a-dimethylnaphthalene-1,6(2H,7H)-dione, (5S)-(-)-3,4,4a,5,6,7,8,8a-octahydro-5,8a-dimethyl-5-(4-methylpent-3-enyl)naphthalen-1(2H)-one ethylene acetal has been synthesized in eight steps involving reductive allylation, deoxygenation, and a Wittig condensation.Transformation of this ethylene acetal via methylation at C-2, Grignard addition, and a Horner-Emmons reaction furnished the required (+)-acid in eight steps.Thus, the absolute stereochemistry of the (+)-acid has been established as (4aS,5S,8aS).