1229407-40-2

Upstream product

• 186132-73-0 2-Bromomethyl-benzoic acid 4-nitro-benzyl ester 

Downstream Products

• 1229407-54-8 4-nitrobenzyl 2-((5-((((1R,2R)-2-(tert-butoxycarbonylamino)cyclohexyl)(methyl)amino)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzoate 
• 1229407-61-7 2-[[5-[[[(1R,2R)-2-[3-(3,5-bis(trifluoromethyl)phenyl)thioureido]cyclohexyl](methyl)amino]methyl]-1H-1,2,3-triazol-1-yl]methyl]benzoic acid 

Relevant academic research and scientific papers

Synthesis of trifunctional thioureas bearing 1,5-disubstituted triazole tether by Ru-catalyzed Huisgen cycloaddition

Synthesis of trifunctional thiourea catalysts tethered with a variety of functional group is described. 1,5-Triazole tether in the catalysts was constructed by ruthenium-catalyzed Huisgen cycloaddition. We demonstrate the utility of the synthetic thioureas as an asymmetric catalyst for Michal addition of nitrostyrene with cyclohexanone.

Synthesis and properties of chiral thioureas bearing an additional function at a remote position tethered by a 1,5- disubstituted triazole

The synthesis and properties of multifunctional thioureas bearing a variety of functional groups at a position remote from the thiourea moiety are described. A 1, 5- disubstituted triazole tether connected with a thiourea and another functional group was synthesized via ruthenium catalyzed Huisgen cycloaddition. We demonstrate the utility of the synthetic thioureas as asymmetric catalysts and probes for the mechanistic elucidation of the course of the Michael reaction of an α,β-unsaturated imide.