1229434-29-0Relevant academic research and scientific papers
Asymmetric synthesis of axially chiral 1-Aryl-5,6,7,8-tetrahydroquinolines by cobalt-catalyzed [2 + 2 + 2] cycloaddition reaction of 1-Aryl-1,7-octadiynes and nitriles
Hapke, Marko,Kral, Karolin,Fischer, Christine,Spannenberg, Anke,Gutnov, Andrey,Redkin, Dmitry,Heller, Barbara
, p. 3993 - 4003 (2010)
The asymmetric synthesis of a range of axially chiral 2-arylpyridines by a cobalt-catalyzed [2 + 2 + 2] cycloaddition reaction is described. The use of a planar chiral (1-neomenthylindenyl)cobalt(COD) complex under photochemical conditions is the key for reacting the 1-naphthyldiynes with a range of differently functionalized nitriles, giving the enantiomeric atropoisomers with high chemical yields and enantiomeric excesses of up to 94% ee.
