122949-67-1

Basic information

• Product Name: 4-amino-1-[(2-hydroxyethoxy)methyl]-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide
• Synonyms: 1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide, 4-amino-1-[(2-hydroxyethoxy)methyl]-
• CAS NO: 122949-67-1
• Molecular Formula: C₉H₁₂N₆O₃
• Molecular Weight: 252.23
• Mol File: 122949-67-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 641.3°C at 760 mmHg
• Flash Point: 341.6°C
• Density: 1.8g/cm³
• Vapor Pressure: 2.53E-17mmHg at 25°C
• Refractive Index: 1.783
• CAS DataBase Reference: 4-amino-1-[(2-hydroxyethoxy)methyl]-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-1-[(2-hydroxyethoxy)methyl]-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide(122949-67-1)
• EPA Substance Registry System: 4-amino-1-[(2-hydroxyethoxy)methyl]-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide(122949-67-1)

Safety Data

• Hazardous Substances Data: 122949-67-1(Hazardous Substances Data)

Upstream product

• 122949-64-8 4-amino-3-cyano-1-<(2-acetoxyethoxy)methyl>pyrazolo<3,4-d>pyrimidine 
• 122949-69-3 4-acetamido-3-cyano-1-<(2-acetoxyethoxy)methyl>pyrazolo<3,4-d>pyrimidine 
• 55559-48-3 4-acetamido-3-cyanopyrazolo<3,4-d>pyrimidine 
• 6826-96-6 4-amino-3-cyano-pyrazolo<3,4-d>pyrimidine 
• 122949-65-9 methyl 4-amino-1-<(2-hydroxyethoxy)methyl>pyrazolo<3,4-d>pyrimidine-3-formimidate 

Relevant articles and documents

Synthesis and Antiviral Activity of Some 7-pyrazolopyrimidine Analogues of Sangivamycin and Toyocamycin

The sodium salt of 4-amino-3-cyanopyrazolopyrimidine (1) was condensed with (2-acetoxyethoxy)methyl bromide (2) to provide the corresponding protected acyclic nucleoside, 4-amino-3-cyano-1-pyrrazolopyrimidine (3).Treatment of 3 with sodium methoxide in methanol provided a good yield of methyl 4-amino-1-pyrrazolopyrimidine-3-formimidate (4).Treatment of the imidate (4) with sodium hydrogen sulfide gave the thiocarboxamide derivative 5.Aqueous base transformed 4 into 4-amino-1pyrrazolopyrimidine-3-carboxamide (6) in good yield.Treatment of 5 with mercuric chloride furnished the toyocamycin analogue 7.Evaluation of compounds 1, 3-7 revealed that only the heterocycle (1) and the thiocarboxamide acyclic nucleoside (5) were active.Compound 5 was the more potent with activity against human cytomegalovirus and herpes simplex virus type 1.