1229512-52-0 Usage
Uses
Used in Pharmaceutical Industry:
1-NaphthaleneMethanaMine, α-Methyl-N-[[3-(trifluoroMethyl)phenyl]Methyl]-, (αR)is used as an impurity in the synthesis of Cinacalcet (C441800) for clinical trials. Cinacalcet is a calcimimetic agent that is used in the treatment of secondary hyperparathyroidism, a condition characterized by the overactivity of the parathyroid glands. The compound plays a crucial role in the development and evaluation of Cinacalcet's efficacy and safety in clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 1229512-52-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,9,5,1 and 2 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1229512-52:
(9*1)+(8*2)+(7*2)+(6*9)+(5*5)+(4*1)+(3*2)+(2*5)+(1*2)=140
140 % 10 = 0
So 1229512-52-0 is a valid CAS Registry Number.
1229512-52-0Relevant academic research and scientific papers
HIGHLY PURE CINACALCET OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
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Page/Page column 45, (2010/07/02)
Provided herein are impurities of cinacalcet, (R)-α-methyl-N-[3-[3-(trifluoromethyl) phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methaneamine (tetrahydro cinacalcet impurity), (R)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1- naphthalenemethaneamine-N-oxide (cinacalcet N-oxide impurity) and (R)-α-methyl-N-[3-[3- (trifiuoromethyl)phenyl]methyl]-1-naphthalenemethaneamine (benzylamine impurity); and processes for preparation and isolation thereof. Provided further herein is a highly pure cinacalcet or a pharmaceutically acceptable salt thereof substantially free of impurities, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure cinacalcet or a pharmaceutically acceptable salt thereof substantially free of impurities.
