1229580-06-6

Basic information

• Product Name: 2,6-dimethyl-4-(1',2'-O-isopropylidene-3'-O-methyl-β-L-threo-pentofuranos-4'-yl)-1-(4-methylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
• Synonyms: 2,6-dimethyl-4-(1',2'-O-isopropylidene-3'-O-methyl-β-L-threo-pentofuranos-4'-yl)-1-(4-methylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
• CAS NO: 1229580-06-6
• Molecular Weight: 515.604
• Mol File: 1229580-06-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-dimethyl-4-(1',2'-O-isopropylidene-3'-O-methyl-β-L-threo-pentofuranos-4'-yl)-1-(4-methylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethyl-4-(1',2'-O-isopropylidene-3'-O-methyl-β-L-threo-pentofuranos-4'-yl)-1-(4-methylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester(1229580-06-6)
• EPA Substance Registry System: 2,6-dimethyl-4-(1',2'-O-isopropylidene-3'-O-methyl-β-L-threo-pentofuranos-4'-yl)-1-(4-methylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester(1229580-06-6)

Safety Data

• Hazardous Substances Data: 1229580-06-6(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 106-49-0 p-toluidine 
• 18968-51-9 1,2-O-isopropylidene-3-O-methyl-α-D-xylo-pentodialdo-1,4-furanose 

Relevant articles and documents

Synthesis and molecular docking studies of 1-phenyl-4-glycosyl-dihydropyridines as potent antileishmanial agents

A series of 1-phenyl-4-glycosyl-dihydropyridines (4-17 and 19-21) were prepared by the one pot multicomponent reaction of glcosyl aldehyde, β-keto compounds and aniline or substituted aniline in the presence of TBAHS as catalyst. The compounds were screened in vitro and in vivo for their antileishmanial activities. Most of the compounds exhibited moderate to good activity against amastigotes and promastigotes of Leishmania donovani. The compounds 4, 11, 12, 13, and 17 exhibited potent in vivo activity with selectivity index (SI) values 7.43-18.93. Molecular docking studies with these compounds revealed L. donovani PTR1 as the possible target to show antileishmanial activities.