1229593-45-6

Basic information

• Product Name: dimethyl 1,3-bis(4-chlorophenyl)-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate
• Synonyms: dimethyl 1,3-bis(4-chlorophenyl)-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate
• CAS NO: 1229593-45-6
• Molecular Weight: 421.28
• Mol File: 1229593-45-6.mol

Chemical Properties

• CAS DataBase Reference: dimethyl 1,3-bis(4-chlorophenyl)-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 1,3-bis(4-chlorophenyl)-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate(1229593-45-6)
• EPA Substance Registry System: dimethyl 1,3-bis(4-chlorophenyl)-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate(1229593-45-6)

Safety Data

• Hazardous Substances Data: 1229593-45-6(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 106-47-8 4-chloro-aniline 
• 762-42-5 dimethyl acetylenedicarboxylate 

Relevant articles and documents

Reaction of dialkyl 2-butynoate with aniline and formaldehyde: revision of the structure of the product

Dimethyl 3-(aryl)-3,6-dihydro-2H-1,3-oxazine-4,5-dicarboxylate structure assigned for the products obtained in the Bronsted acid catalyzed reaction of dimethyl but-2-ynoates with anilines and an excess of formaldehyde in methanol has been revised to methy

Nano-MoO3 as a highly efficient heterogeneous catalyst for a one-pot synthesis of tetrahydropyrimidine derivatives in water

A green and highly efficient one-pot synthesis of 16 1,3,4,5-tetrasubstituted 1,2,3,6-tetrahydropyrimidines, four of which are new, using a three-component reaction involving an aniline, formaldehyde and a dialkyl acetylenedicarboxylate in aqueous media at room temperature catalysed by nano-MoO3 has been achieved.

Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity

It is the first report of 1,3,4,5-tetrasubstituted 1,2,3,6- tetrahydropyrimidines derivatives, catalyzed by ZrOCl2. The mild reaction conditions, excellent yields in shorter reaction time and evasion of cumbersome workup procedures make this pr

Efficient synthesis of tetrahydropyrimidines and pyrrolidines by a multicomponent reaction of dialkyl acetylenedicarboxylates (=dialkyl but-2-ynedioates), amines, and formaldehyde in the presence of iodine as a catalyst

Iodine was explored as an efficient catalyst for the synthesis of tetrahydropyrimidines 4 and pyrrolidines 5 by a multicomponent reaction of dialkyl acetylenedicarboxylates (=dialkyl but-2-ynedioates) 1, amines 2, and HCHO 3 at room temperature (Scheme).

An efficient multicomponent synthesis of polysubstituted pyrrolidines and tetrahydropyrimidines starting directly from nitro compounds in water

A distinct approach for the synthesis of 1,3,3-trisubstituted 4,5-dioxopyrrolidines and 1,3,4,5-tetrasubstituted 1,2,3,6-tetrahydropyrimidines has been discovered, in the form of a three-component reaction of nitroarenes, formaldehyde, and dialkyl acetylenedicarboxylates using indium in dilute aqueous HCl at room temperature. The molar ratios of these substrates are 1:1:4 and 2:1:4 for the preparation of dioxopyrrolidines and tetrahydropyrimidines, respectively. The reactions involve the reduction of nitro compounds to amines, which are simultaneously attacked by dialkyl acetylenedicarboxylates and formaldehyde. The products are formed in good to high yields. Georg Thieme Verlag Stuttgart.