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1229618-15-8

1229618-15-8

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1229618-15-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1229618-15-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,9,6,1 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1229618-15:
(9*1)+(8*2)+(7*2)+(6*9)+(5*6)+(4*1)+(3*8)+(2*1)+(1*5)=158
158 % 10 = 8
So 1229618-15-8 is a valid CAS Registry Number.

1229618-15-8Relevant articles and documents

Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists

Ullrich, John W.,Morris, Robert,Bernotas, Ronald C.,Travins, Jeremy M.,Jetter, James,Unwalla, Rayomand,Quinet, Elaine,Nambi, Ponnal,Feingold, Irene,Huselton, Christine,Enroth, Christofer,Wilhelmsson, Anna,Goos-Nilsson, Annika,Wrobel, Jay

scheme or table, p. 2903 - 2907 (2010/08/05)

A series of 4-(3-biaryl)quinolines with sulfone substituents on the terminal aryl ring (8) was prepared as potential LXR agonists. High affinity LXRβ ligands with generally modest binding selectivity over LXRα and excellent agonist potency in LXR functional assays were identified. Many compounds had LXRβ binding IC50 values 50 values 1.0 nM in an ABCA1 mRNA induction assay in J774 mouse cells with efficacy comparable to T0901317. Sulfone 8a was further evaluated in LDL (-/-) mice and shown to reduce atherosclerotic lesion progression.

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