1229622-72-3

Upstream product

• 1229622-81-4 di-tert-butyl (9-trityl-9H-purin-6-yl)-di-carbamate 
• 76-83-5 trityl chloride 
• 66224-66-6 adenine 

Downstream Products

• 1229622-73-4 C₃₃H₃₅N₅O₂ 
• 870281-82-6 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one 

Relevant academic research and scientific papers

PROCESSES FOR PREPARATION OF IDELALISIB AND INTERMEDIATES THEREOF

The present application provides processes for preparation of Idelalisib and intermediates thereof. The present application also provides a process for purification of Idelalisib.

Regioselective alkylation of the exocyclic nitrogen of adenine and adenosine by the Mitsunobu reaction

A novel synthetic route to N6-substitution of adenine is presented, employing the Mitsunobu reaction as the key step. A range of primary and secondary alcohols all coupled in very good to excellent yields within 30 min at 45 °C, offering a milder alternative to the traditional nucleophilic aromatic substitution of 6-chloropurine. The utility of this protocol is further demonstrated by its application to the syntheses of N6,N9-di-substituted adenines, including the potent and selective A1 adenosine receptor agonist N6-cyclopentyladenosine.