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Usage

Uses

Used in Organic Synthesis:
Benzoic acid, 2-fluoro-5-sulfinois used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for the creation of a wide range of products, making it a versatile component in this field.
Used in Pharmaceutical Production:
As a building block for the production of pharmaceuticals, benzoic acid, 2-fluoro-5-sulfinoplays a crucial role in the development of new drugs. Its potential applications in medicine and drug development are significant due to its ability to inhibit certain enzymes, which can be harnessed for therapeutic purposes.
Used in Agrochemicals:
Benzoic acid, 2-fluoro-5-sulfinois also utilized in the production of agrochemicals, contributing to the development of more effective and targeted products for agricultural use.
Used in Fine Chemicals Industry:
Benzoic acid, 2-fluoro-5-sulfinois further used in the synthesis of fine chemicals, which are high-purity, specialty chemicals used in various applications, including research, pharmaceuticals, and other industries.
Used in Biochemical Research:
Due to its enzyme-inhibiting properties, benzoic acid, 2-fluoro-5-sulfinois of interest in biochemical research. It can be employed in studies aimed at understanding enzyme functions and developing new methods for their manipulation, which can lead to advancements in medicine and biotechnology.

Upstream product

• 445-29-4 o-fluoro-benzoic acid 
• 37098-75-2 2-fluoro-5-chlorosulfonylbenzoic acid 

Relevant academic research and scientific papers

2-Substituted-phenyl-oxy-5-methylsulfonyl piperazine acidamide analogue and preparation method and application thereof

The invention discloses 2-substituted-phenyl-oxy-5-methylsulfonyl piperazine acidamide analogue and a preparation method and application thereof, and particularly, relates to 2-substituted-phenyl-oxy-5-methylsulfonyl piperazine acidamide analogue with a formula (I) compound and a preparation method and application thereof, wherein substitutions in the formula (I) compound are defined as in the description. This serial compound can inhibit the activity of glycine transport protein-1 (GlyT1), is useful in treating related diseases in central nerve and psychological fields, for example, schizophrenia (including positive symptoms, negative symptoms and cognitive symptoms), senile dementia, Parkinson's disease and other related psychological diseases, is widely applicable to the drugs for preventing and treating central nerve and psychological diseases, and is expected to be developed into new-generation GlyT1 inhibitors.

Selective GlyT1 inhibitors: Discovery of [4-(3-fluoro-5- trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2, 2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia

The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia. Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine class of GlyT1 inhibitors to improve hERG channel selectivity and brain penetration. This effort culminated in the discovery of compound 10a (RG1678), the first potent and selective GlyT1 inhibitor to have a beneficial effect in schizophrenic patients in a phase II clinical trial.

Heterocyclic-substituted phenyl methanones

The present invention relates to compounds of formula I wherein R1, R2, and are defined in the specification and to pharmaceutically acceptable acid addition salts thereof.