1229643-41-7

Basic information

• Product Name: bis-[(3,4,5-trimethoxybenzyl)czclopentadienyl]molybdenum(IV) dichloride
• CAS NO: 1229643-41-7
• Molecular Weight: 657.442
• Mol File: 1229643-41-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: bis-[(3,4,5-trimethoxybenzyl)czclopentadienyl]molybdenum(IV) dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: bis-[(3,4,5-trimethoxybenzyl)czclopentadienyl]molybdenum(IV) dichloride(1229643-41-7)
• EPA Substance Registry System: bis-[(3,4,5-trimethoxybenzyl)czclopentadienyl]molybdenum(IV) dichloride(1229643-41-7)

Safety Data

• Hazardous Substances Data: 1229643-41-7(Hazardous Substances Data)

Upstream product

• 13320-71-3 molybdenum(IV) chloride 

Relevant articles and documents

Novel benzyl-substituted molybdocene anticancer drugs

From the reaction of 6-(p-methoxyphenyl) fulvene (1a), 6-(3,4-dimethoxyphenyl) fulvene (1b) and 6-(3,4,5-trimethoxyphenyl) fulvene (1c) with LiBEt3H, lithiated cyclopentadienide intermediates (2a-c) were synthesised. These intermediates were then transmetallated to molybdocene using MoCl4 (synthesized in situ) to yield the benzyl-substituted molybdocenes bis-[(p-methoxybenzyl)cyclopentadienyl] molybdenum (IV) dichloride (3a), bis-[(3,4-dimethoxybenzyl)cyclopentadienyl] molybdenum (IV) dichloride (3b), and bis-[(3,4,5-trimethoxybenzyl)cyclopentadienyl] molybdenum (IV) dichloride (3c). The molybdocene 3a was characterised by single crystal X-ray diffraction. All three molybdocenes had their cytotoxicity investigated through MTT based preliminary in vitro testing on the human renal cell line Caki-1 in order to determine their IC50 values and compare them with the corresponding titanocene and vanadocene dichloride derivatives. Molybdocenes 3b-c were found to have the same IC50 values of 290 μM, while 3a yielded a value of 84 μM, respectively.