1229652-75-8Relevant academic research and scientific papers
Synthesis of (-)-paroxetine via enantioselective phase-transfer catalytic monoalkylation of malonamide ester
Kim, Mi-Hyun,Park, Yohan,Jeong, Byeong-Seon,Park, Hyeung-Geun,Jew, Sang-Sup
supporting information; experimental part, p. 2826 - 2829 (2010/08/07)
(Figure presented) A new enantioselective synthetic method of (-)-paroxetine is reported. (-)-Paroxetine could be obtained in 15 steps (95% ee and 9.1% overall yield) from N,N-bis(p-methoxyphenyl)malonamide tert-butyl ester via the enantioselective phase-transfer catalytic alkylation and the diastereoselective Michael addition as the key steps.
