1229653-76-2Relevant academic research and scientific papers
Cyclopeptide Smac mimetics as antagonists of IAP proteins
Sun, Haiying,Liu, Liu,Lu, Jianfeng,Qiu, Su,Yang, Chao-Yie,Yi, Han,Wang, Shaomeng
, p. 3043 - 3046 (2010)
Two cyclopeptidic Smac mimetics, 2 and 3, were designed and synthesized. These two compounds bind to XIAP and cIAP-1/2 with low nanomolar affinities, and restore the activities of caspase-9 and caspase-3/-7 inhibited by XIAP. Compound 2 potently inhibits
