1229681-46-2Relevant academic research and scientific papers
Chromene-based synthetic chalcones as potent antileishmanial agents: Synthesis and biological activity
Foroumadi, Alireza,Emami, Saeed,Sorkhi, Maedeh,Nakhjiri, Maryam,Nazarian, Zohreh,Heydari, Samaneh,Ardestani, Sussan K.,Poorrajab, Fatemeh,Shafiee, Abbas
, p. 590 - 596 (2011/04/17)
Two types of regioisomeric chromene-based chalcones namely, 1-(6-methoxy-2H-chromen-3-yl)-3-phenylpropen-1-ones and 3-(6-methoxy-2H-chromen- 3-yl)-1-phenylpropen-1-ones were prepared and investigated for their antileishmanial activity against promastigotes form of Leishmania major. The obtained results from in vitro biological assays indicated that chloro-substituted 1-(6-methoxy-2H-chromen-3-yl)-3-phenylpropen-1-ones exhibited excellent activity against Leishmania major at non-cytotoxic concentrations.
