1229699-55-1

Upstream product

• 108-86-1 bromobenzene 
• 22286-82-4 2-phenyl-acrylic acid ethyl ester 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 497-25-6 dimethylenecyclourethane 
• 492-38-6 2-phenylacrylic acid 
• 51491-68-0 2-phenylacrylyl chloride 

Downstream Products

• 1346947-97-4 C₁₅H₁₃NOS 
• 1346946-80-2 C₁₈H₁₇NO₃S 
• 1346947-59-8 C₁₈H₁₈N₂O₃S 
• 1428671-74-2 (R)-S-(3-oxo-3-(2-oxooxazolidin-3-yl)-2-phenylpropyl) ethanethioate 

Relevant academic research and scientific papers

Enantioselective enolate protonation in sulfamichael addition to r-substituted n-acryloyloxazolidin-2-ones with bifunctional organocatalyst

Organocatalytic conjugate addition of thiols to R-substituted N-acryloyloxazolidin-2-ones followed by asymmetric protonation has been studied in the presence of cinchona alkaloid derived thioureas. Both of the enantiomers are accessible with the same level of enantioselectivity using pseudoenantiomeric quinine/quinidine derived catalysts. The addition/protonation products have been converted to useful biologically active molecules. 2011 American Chemical Society.

Catalytic asymmetric protonation of chiral calcium enolates via 1,4-addition of malonates

Catalytic asymmetric protonation of chiral calcium enolates was performed. Chiral calcium enolates, prepared in situ from imides and malonates via 1,4-addition in the presence of catalytic amounts of Ca(OEt)2, Ph-PyBox, and achiral phenol, were smoothly protonated to afford adducts bearing tertiary asymmetric carbons in high yields with high enantioselectivities. The adducts were readily converted to optically active 2-substituted 1,5-dicarboxylic acid derivatives.