122973-87-9Relevant academic research and scientific papers
INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
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Page/Page column 92, (2016/11/17)
Compounds of Formulas I-VI, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth. Formula I is exemplified below: Formula (i)
GE-180: A novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO)
Wadsworth, Harry,Jones, Paul A.,Chau, Wai-Fung,Durrant, Clare,Fouladi, Naghmeh,Passmore, Joanna,O'Shea, Dennis,Wynn, Duncan,Morisson-Iveson, Veronique,Ewan, Amanda,Thaning, Mikkel,Mantzilas, Dimitrios,Gausemel, Ingvil,Khan, Imtiaz,Black, Andrew,Avory, Michelle,Trigg, William
scheme or table, p. 1308 - 1313 (2012/04/04)
A series of tricyclic compounds have been synthesised and evaluated in vitro for affinity against Translocator protein 18 kDa (TSPO) and for preferred imaging properties. The most promising of the compounds were radiolabelled and evaluated in vivo to determine biodistribution and specificity for high expressing TSPO regions. Metabolite profiling in brain and plasma was also investigated. Evaluation in an autoradiography model of neuroinflammation was also carried out for the best compound, 12a ([18F]GE-180).
