1229806-01-2Relevant academic research and scientific papers
Camphor-derived C1-symmetric chiral diamine organocatalysts for asymmetric Michael addition of nitroalkanes to enones
Zhou, Yirong,Liu, Qiang,Gong, Yuefa
, p. 7618 - 7627 (2012/10/29)
A series of stable C1-symmetric chiral diamines (2a-2l) were conveniently synthesized by condensing exo-(-)-bornylamine or (+)-(1S,2S,5R)-menthylamine with various commercially available Cbz-protected amino acids. Among them, 2a can efficiently promote the Michael addition of nitroalkanes to a broad scope of enones with high yields (up to 96%) and excellent enantioselectivities (up to 98%) under mild conditions.
Organocatalyzed enantioselective Michael additions of nitroalkanes to enones by using primary-secondary diamine catalysts
Yang, Ying-Quan,Chen, Xin-Kuan,Xiao, Hua,Liu, Wen,Zhao, Gang
supporting information; experimental part, p. 4130 - 4132 (2010/08/19)
Primary-secondary diamines perform as efficient organocatalysts for the asymmetric addition of nitroalkanes to enones, giving the Michael adducts with excellent yields and enantioselectivities.
