122996-35-4Relevant academic research and scientific papers
Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor
Sun, Weiguang,Wu, Yanli,Zheng, Mengzhu,Yang, Yueying,Liu, Yang,Wu, Canrong,Zhou, Yirong,Zhang, Yonghui,Chen, Lixia,Li, Hua
supporting information, p. 8146 - 8156 (2020/09/21)
Tumor necrosis factor α (TNF-α) is an important therapeutic target for rheumatoid arthritis, inflammatory bowel disease, and septic hepatitis. In this study, structure-based virtual ligand screening combined with in vitro and in vivo assays were applied.
Compound with TNF-alpha inhibition activity and application thereof
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Paragraph 0006, (2020/07/13)
The invention provides a compound shown in a formula I, wherein substituent groups are defined in the specification. The provided compound is an effective TNF-alpha inhibitor, which can be used to treat autoimmune diseases.
Methods for making optically active 3-aminopyrrolidine-2,5-dione derivative and optically active 3-aminopyrrolidine derivative
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Example 3, (2008/06/13)
A method for making an optically active 3-aminopyrrolidine-2,5-dione derivative represented by the formula (3) includes cyclizing an optically active asparagine ester derivative represented by the formula (1) or (2) or an acid salt thereof. The optically active 3-aminopyrrolidine-2,5-dione derivative represented by the formula (3) may be reduced to form an optically active 3-aminopyrrolidine derivative represented by the formula (9). When, in the formula (9), R1 is an unsubstituted or substituted benzyl group, the compound may be hydrogenated to obtain the corresponding 1-unsubstituted compound in which R1 is hydrogen.
Process for preparing 3-amino-1-benzylpyrrolidines
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, (2008/06/13)
A process for preparing a 3-amino-1-benzyl-pyrrolidine of the formula STR1 in which R1 and R2 each independently is H or alkyl, and Ph is phenyl, comprising reacting a 1-benzyl-Δ3 -pyrroline-2,5-dione of the formula STR2 in which R3 and R4 each independently is H or alkyl, with a nitrogen nucleophile of the formula in which R5 is H, benzyl, naphthylmethyl or phenyl-CHR6, and R6 is C1 -C6 -alkyl or phenyl, to give an optionally substituted 3-amino-1-benzylpyrrolidine-2,5-dione of the formula STR3 and, if R5 ≠H, the protecting group R5 is subsequently cleaved off to give a 3-amino-1-benzylpyrrolidine-2,5-dione of the formula STR4 and completely reducing the carbonyl groups to form the 3-amino-1-benzylpyrrolidine of the formula (I).
Synthesis and anticonvulsant activity of racemic 2-amino-N-substituted succinimide derivatives
Crider,Kolczynski,Miskell
, p. 192 - 195 (2007/10/02)
Several derivatives of (R,S)-2-amino-N-substituted succinimides were synthesized and evaluated in mice against seizures produced by electroshock and pentylenetetrazol. The most active compound against both electroshock- and pentylenetetrazol-induced seizu
