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123-46-6

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123-46-6 Usage

Chemical Properties

white to almost white crystalline powder

Uses

Different sources of media describe the Uses of 123-46-6 differently. You can refer to the following data:
1. Girard''s Reagent T is a derivatizing agent used to generate permanent cationic charge at the reducing ends of neutral oligosaccharides for easier quantification in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).
2. Girard′s reagent T may be used as a derivatizing reagent for the determination of 5-Formyl-2′-deoxyuridine in cellular DNA samples using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique. Reducing saccharides can be derivatized by Girard′s reagent T and this can be analyzed by matrix-assisted laser desorption/ionization coupled to time of flight mass spectrometry (MALDI-TOF-MS) technique.

Purification Methods

It is purified by crystallisation from absolute EtOH (slight decomposition) until it has only a slight odour. Store it in well-stoppered containers because it is very hygroscopic. It is very soluble in H2O, AcOH and glycerol but slightly soluble in EtOH (0.66%). It forms water-soluble hydrazones with carbonyl compounds. [Beilstein 4 III 1133.]

Check Digit Verification of cas no

The CAS Registry Mumber 123-46-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 123-46:
(5*1)+(4*2)+(3*3)+(2*4)+(1*6)=36
36 % 10 = 6
So 123-46-6 is a valid CAS Registry Number.

123-46-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Sigma-Aldrich

  • (89397)  Girard’sreagentT  for HPLC derivatization, 99.0-101.0% (AT)

  • 123-46-6

  • 89397-1G

  • 189.54CNY

  • Detail
  • Sigma-Aldrich

  • (89397)  Girard’sreagentT  for HPLC derivatization, 99.0-101.0% (AT)

  • 123-46-6

  • 89397-10G

  • 258.57CNY

  • Detail
  • Sigma-Aldrich

  • (89397)  Girard’sreagentT  for HPLC derivatization, 99.0-101.0% (AT)

  • 123-46-6

  • 89397-10X1G

  • 237.51CNY

  • Detail
  • Aldrich

  • (G900)  Girard’sreagentT  99%

  • 123-46-6

  • G900-100G

  • 1,068.21CNY

  • Detail

123-46-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Girard's Reagent T

1.2 Other means of identification

Product number -
Other names GIRARD T

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123-46-6 SDS

123-46-6Relevant articles and documents

Limitations of the "tethering" strategy for the detection of a weak noncovalent interaction

Gasparini, Giulio,Martin, Marco,Prins, Leonard J.,Scrimin, Paolo

, p. 1340 - 1342 (2007)

The success of applying the tethering strategy in a synthetic molecular system strongly depends on the experimental conditions and is related to the strength of the noncovalent interaction and the competition between the 'captured' and unbound ligand for the recognition site. The Royal Society of Chemistry.

Controlled release of volatile aldehydes and ketones from dynamic mixtures generated by reversible hydrazone formation

Levrand, Barbara,Fieber, Wolfgang,Lehn, Jean-Marie,Herrmann, Andreas

, p. 2281 - 2314 (2008/03/29)

Delivery systems generated by reversible hydrazone formation from hydrazine derivatives (see Fig. 1) and carbonyl compounds in H2O efficiently increase the long-lastingness of volatile aldehydes and ketones (R 1R2C=O) in various perfumery applications. The hydrazones are usually obtained in an (E) configuration at the imine double bond (NHN=C) and, in the case of aliphatic acylhydrazones R′CO-NH-N=CR 1R2 (R′ = alkyl), as syn and anti conformers with respect to the amide bond (CO-NHN). An average free-energy barrier of ca. 78kJ/mol was determined for the amide-bond rotation by variable-temperature 1H-NMR measurements (Fig. 2). In the presence of H2O, the hydrazone formation is entirely reversible, reaching an equilibrium composed of the hydrazine derivative, the carbonyl compound, and the corresponding hydrazone. Kinetic measurements carried out by UV/VIS spectroscopy showed that the same equilibrium was reached for the formation and hydrolysis of the hydrazone. Rate constants are strongly pH-dependent and increase with decreasing pH (Table 1). The influence of the hydrazine structure on the rate constants is less pronounced than the pH effect, and the presence of surfactants reduces the rate of equilibration (Tables 1 and 3). The full reversibility of the hydrazone formation allows to prepare dynamic mixtures by simple addition of a hydrazine derivative to several carbonyl compounds. Dynamic headspace analysis on dry cotton showed that the presence of a hydrazine derivative significantly increased the headspace concentrations of the different carbonyl compounds as compared to the reference sample without hydrazine (Table 4). The release of the volatiles was found to be efficient for fragrances with high vapor pressures and low H2O solubility. Furthermore, a special long-lasting effect was obtained for the release of ketones. The simplicity of generating dynamic mixtures combined with the high efficiency for the release of volatiles makes these systems particularly interesting for practical applications and will certainly influence the development of delivery systems in other areas such as the pharmaceutical or agrochemical industry.

Controlled release of volatile aldehydes and ketones by reversible hydrazone formation - "Classical" profragrances are getting dynamic

Levrand, Barbara,Ruff, Yves,Lehn, Jean-Marie,Herrmann, Andreas

, p. 2965 - 2967 (2008/09/20)

Dynamic mixtures obtained by reversible covalent acylhydrazone formation of fragrance aldehydes and/or ketones and a hydrazide in water were found to be efficient delivery systems for the controlled release of highly volatile organic molecules. The Royal Society of Chemistry 2006.

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