123001-21-8

Basic information

• Product Name: (+)-(4S,5R)-4-(2-Benzyloxyethyl)-5-ethyl-3,4,5,6-tetrahydro-2-pyrone
• CAS NO: 123001-21-8
• Molecular Weight: 262.349
• Mol File: 123001-21-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+)-(4S,5R)-4-(2-Benzyloxyethyl)-5-ethyl-3,4,5,6-tetrahydro-2-pyrone(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(4S,5R)-4-(2-Benzyloxyethyl)-5-ethyl-3,4,5,6-tetrahydro-2-pyrone(123001-21-8)
• EPA Substance Registry System: (+)-(4S,5R)-4-(2-Benzyloxyethyl)-5-ethyl-3,4,5,6-tetrahydro-2-pyrone(123001-21-8)

Safety Data

• Hazardous Substances Data: 123001-21-8(Hazardous Substances Data)

Upstream product

• 601-75-2 ethylmalonic acid 
• 1325690-29-6 C₁₉H₂₆O₆ 
• 122778-44-3 (1R,3R,4S)-p-menthan-3-yl (2R)-2-(dimethyl-t-butylsiloxymethyl)butyrate 
• 115698-64-1 (+)-(4S,5R)-4-(2-Benzyloxyethyl)-2-ethoxy-5-ethyl-3,4,5,6-tetrahydro-2H-pyran 
• 115698-64-1 (R)-4-(2-Benzyloxy-ethyl)-2-ethoxy-5-ethyl-tetrahydro-pyran 
• 122937-62-6 (-)-Methyl (4R)-(Z)-4-(2-Bromo-1-ethoxyethoxymethyl)hex-2-enoate 
• 131815-09-3 2-((R)-2-Ethoxy-5-ethyl-tetrahydro-pyran-4-yl)-ethanol 
• 115698-71-0 (-)-Ethyl (4R)-(E)-4-(2-Bromo-1-ethoxyethoxymethyl)hex-2-enoate 
• 115698-54-9 (+)-(5R)-2-Ethoxy-4-ethoxycarbonylmethyl-5-ethyl-3,4,5,6-tetrahydro-2H-pyran 
• 131814-98-7 (+)-(1S,3S,4R)-p-Menthan-3-yl (2S)-2-Hydroxymethylbutyrate 
• 122937-63-7 (-)-(4R,5R)-2-Ethoxy-5-ethyl-4-methoxycarbonylmethyl-3,4,5,6-tetrahydro-2H-pyran 
• 122937-61-5 (+)-(2R)-(2-Bromo-1-ethoxyethoxymethyl)butan-1-ol 
• 122937-62-6 (Z)-(R)-4-(2-Bromo-1-ethoxy-ethoxymethyl)-hex-2-enoic acid methyl ester 
• 111042-76-3 (-)-(2S)-2-((tert-Butyldimethylsiloxy)methyl)butan-1-ol 

Downstream Products

• 122937-64-8 (+)-(3S,4R)-3-(2-Benzyloxyethyl)-N-(3,4-dimethoxyphenethyl)-4-hydroxymethylhexacarboxamide 
• 122937-65-9 (-)-(2R,3R,11bS)-2-(2-Benzyloxyethyl)-3-ethyl-1,2,3,4,6,7-hexahydro-9,10-dimethoxy-11bH-benzoquinolizidine 
• 549-91-7 (-)-Protoemetine 
• 2270-72-6 Dihydrocorynantheol 
• 132216-06-9 (2R,3R)-2-(2-Benzyloxy-ethyl)-3-ethyl-2,3,4,6,7,12-hexahydro-1H-indolo[2,3-a]quinolizin-5-ylium; chloride 
• 132216-04-7 Methanesulfonic acid (2R,3S)-5-benzyloxy-2-ethyl-3-{[2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-pentyl ester 
• 132296-31-2 (4S,5R)-(+)-4-(2-benzyloxyethyl)-5-ethyl-N-<2-(indol-3-yl)ethyl>piperidin-2-one 
• 132216-10-5 (2R,3R)-2-(2-Benzyloxy-ethyl)-3-ethyl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine 

Relevant articles and documents

Organocatalytic approach for the syntheses of corynantheidol, dihydrocorynantheol, protoemetinol, protoemetine, and mitragynine

O-Trimethylsilyl (TMS)-protected diphenylprolinol-catalyzed Michael addition of a functionalized alkylidene malonate and n-butanal affords an aldehyde. This adduct can serve as the common intermediate for the assembly of secologanin tryptamine and dopamin

HIGHLY ENANTIOCONTROLLED TOTAL SYNTHESYS OF (-)-PROTOEMETINOL

Enantiomerically pure (-)-protoemetinol (1) was selectively synthesized from ethylmalonic acid via radical cyclization of the (Z)-α,β-unsaturated ester (12).