123016-15-9

Upstream product

• 4377-41-7 2-Chloromethylquinoline 
• 52079-10-4 6-hydroxy-α-methyl-2-naphthaleneacetic acid 
• 123016-30-8 α-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid methyl ester 

Downstream Products

• 177735-71-6 N-[2-(1H-5-tetrazolyl)phenylmethyl]-2-[6-(2-quinolinylmethoxy)-2-naphthyl]propanamide 
• 177735-70-5 N-[3-(1H-5-tetrazolyl)phenylmethyl]-2-[6-(2-quinolinylmethoxy)-2-naphthyl]propanamide 
• 177735-72-7 N-(4-cyanomethylphenyl)-2-[6-(2-quinolinylmethoxy)-2-naphthyl]propanamide 

Relevant academic research and scientific papers

NAPHTHALENE AMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION

Naphthalene amides of formula (I) wherein the substituent containing A is bound to the 6- or 7- position of the 2-naphthol system; the substituent containing B is bound to the benzene ring at any free position; R is hydrogen or methyl; R is hydrogen, fluorine, chlorine or -OCH3, which is bound to the naphthalene system at any positions except the 2- and the one occupied by the other substituent; R is hydrogen, fluorine, chlorine or bromine; A- is -CO-NR- or -NR-CO- group, wherein R is hydrogen or methyl; B is a 5-tetrazolyl or -COOR group, wherein R is hydrogen, a (C1-C4)-alkyl or a phenylalkyl group of less than 10 carbon atoms; m is 0 or 1; n and p are integers from 0 to 6, with the proviso that n + p is less or equal to 6; as well as the solvates and pharmaceutically acceptable salts thereof, have leukotriene antagonistic action.

NAPHTHALENEPROPIONIC ACID DERIVATIVES AS ANTI-INFLAMMATORY / ANTIALLERGIC AGENTS

There are disclosed compounds of the formula STR1 wherein A is alkyl of 3-19 carbon atoms, diloweralkyl allyl, dihaloallyl, diphenylallyl, lower alkynyl, STR2 with the proviso that A is not quinolinyl; W is--CR. sub.2 O--,--CH=CH--or--CH=CHCH 2 O--; X is N or CR;Z is STR3--S--or--O--; R is hydrogen or lower alkyl;Y is STR4 R. sup.1 is hydrogen, lower alkyl or phenyl; R 2 is hydrogen or lower alkyl; orR 1 and R 2 taken together form a benzene ring, optionally substituted by halo;R 3 is--OR, STR5 or--NHSO 2 R 4 ; R 4 is phenyl or loweralkyl substituted phenyl;and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.

Quinolinylmethoxy naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents

There are disclosed compounds of the formula STR1 wherein R is hydrogen or lower alkyl; Y is STR2 or a pharmaceutically acceptable salt thereof, and its use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.

Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents

There are disclosed compounds of the formula STR1 wherein a is alkyl 3-19 carbon atoms, diloweralkyl allyl, diahaloallyl, diphenylallyl, lower alkynyl, STR2 W is --CR2 O--, --CH=CH-- or --CH=CHCH2 O-- X is N or CR; Z is STR3 R is hydrogen or lower alkyl; Y is STR4 R1 is hydrogen, lower alkyl or phenyl; R2 is hydrogen or lower alkyl; or R1 and R2 taken together form a benzene ring, optionally substituted by halo; R3 is --OR, STR5 -- NHSO2 R4 ; R4 is phenyl or loweralkyl substituted phenyl; R5 is halo; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as alelrgic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.

Naphthalenepropionic acid derivatives as anti-inflammatory/anti-allergic agents

There are disclosed compounds of the formula STR1 wherein A is alkyl of 3-19 carbon atoms, diloweralkyl allyl, dihaloallyl, diphenylallyl, lower alkynyl, STR2 X is N or CR; Z is STR3 R is hydrogen or lower alkyl; R1 is hydrogen, lower alkyl or phenyl; R2 is hydrogen or loweralkyl; or R1 and R2 taken together form a benzene ring; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.