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123036-51-1

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123036-51-1 Usage

General Description

3-Aminophenylacetic acid, N-BOC protected, is a chemical compound with the molecular formula C11H15NO4. It is a derivative of aminophenylacetic acid with a tert-butoxycarbonyl (BOC) group protecting the amine functional group. 3-Aminophenylacetic acid, N-BOC protected is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceutical compounds. The BOC protecting group allows for the selective deprotection of the amine group under specific conditions, making it a versatile tool in chemical synthesis. It can be used in the preparation of peptides, amino acids, and other biologically active molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 123036-51-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,0,3 and 6 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 123036-51:
(8*1)+(7*2)+(6*3)+(5*0)+(4*3)+(3*6)+(2*5)+(1*1)=81
81 % 10 = 1
So 123036-51-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H17NO4/c1-13(2,3)18-12(17)14-10-6-4-5-9(7-10)8-11(15)16/h4-7H,8H2,1-3H3,(H,14,17)(H,15,16)

123036-51-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Boc-3-aminophenylacetic Acid

1.2 Other means of identification

Product number -
Other names N-Boc-3-Aminophenylacetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123036-51-1 SDS

123036-51-1Relevant articles and documents

Fibril-forming model synthetic peptides containing 3-aminophenylacetic acid

Maji, Samir Kumar,Haldar, Debasish,Banerjee, Arijit,Banerjee, Arindam

, p. 8695 - 8702 (2002)

The FT-IR, 1H NMR, electrospray mass spectrometry studies of several dipeptides containing 3-APA (3-aminophenylacetic acid) and Aib/Val/Pro, revealed that all peptides share a common structural feature, an extended backbone conformation and they form the intermolecular hydrogen bonded supramolecular β-sheet structure in the solid state. The SEM images of all peptides exhibit amyloid-like fibrils, reminiscent of many neurodegenerative diseases like Alzheimer's, Prion-protein diseases.

Hypoxia-Activated Prodrugs of PERK Inhibitors

Liew, Lydia P.,Singleton, Dean C.,Wong, Way W.,Cheng, Gary J.,Jamieson, Stephen M. F.,Hay, Michael P.

, p. 1238 - 1248 (2019/02/05)

Tumour hypoxia plays an important role in tumour progression and resistance to therapy. Under hypoxia unfolded proteins accumulate in the endoplasmic reticulum (ER) and this stress is relieved through the protein kinase R-like ER kinase (PERK) signalling

Pharmacomodulation of the antimalarial plasmodione: Synthesis of biaryl-and N-arylalkylamine analogues, antimalarial activities and physicochemical properties

Urgin, Karène,Jida, Mouhamad,Ehrhardt, Katharina,Müller, Tobias,Lanzer, Michael,Maes, Louis,Elhabiri, Mourad,Davioud-Charvet, Elisabeth

, (2017/02/15)

With the aim of increasing the structural diversity on the early antimalarial drug plasmodione, an efficient and versatile procedure to prepare a series of biaryl- and N-arylalkylamines as plasmodione analogues is described. Using the naturally occurring and commercially available menadione as starting material, a 2-step sequence using a Kochi-Anderson reaction and subsequent Pd-catalyzed Suzuki-Miyaura coupling was developed to prepare three representative biphenyl derivatives in good yields for antimalarial evaluation. In addition, synthetic methodologies to afford 3-benzylmenadione derivatives bearing a terminal -N(Me)2 or -N(Et)2 in different positions (ortho, meta and para) on the aryl ring of the benzylic chain of plasmodione were investigated through reductive amination was used as the optimal route to prepare these protonable N-arylalkylamine privileged scaffolds. The antimalarial activities were evaluated and discussed in light of their physicochemical properties. Among the newly synthesized compounds, the para-position of the substituent remains the most favourable position on the benzyl chain and the carbamate -NHBoc was found active both in vitro (42 nM versus 29 nM for plasmodione) and in vivo in Plasmodium berghei-infected mice. The measured acido-basic features of these new molecules support the cytosol-food vacuole shuttling properties of non-protonable plasmodione derivatives essential for redox-cycling. These findings may be useful in antimalarial drug optimization.

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