123053-22-5 Usage
Uses
Used in Scientific Research:
L-3-Chlorophenylalanine is used as a research tool for studying the effects of altered phenylalanine metabolism and the role of phenylalanine hydroxylase in various physiological processes. Its ability to inhibit phenylalanine hydroxylase makes it a valuable compound for investigating the consequences of disrupted phenylalanine metabolism on cellular and organismal functions.
Used in Neurological Research:
L-3-Chlorophenylalanine is used as a research compound in the field of neurology to understand its potential role in regulating neurotransmitter levels in the brain. This knowledge can contribute to the development of new therapeutic interventions for neurological disorders associated with neurotransmitter imbalances.
Used in Drug Development:
L-3-Chlorophenylalanine is used as a starting material or a key intermediate in the synthesis of pharmaceutical compounds targeting phenylalanine hydroxylase or neurotransmitter regulation. Its unique properties and inhibitory effects on phenylalanine hydroxylase make it a promising candidate for the development of drugs aimed at treating neurological disorders and other conditions related to phenylalanine metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 123053-22-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,0,5 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 123053-22:
(8*1)+(7*2)+(6*3)+(5*0)+(4*5)+(3*3)+(2*2)+(1*2)=75
75 % 10 = 5
So 123053-22-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H10ClNO2/c10-7-3-1-2-6(4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m1/s1
123053-22-5Relevant academic research and scientific papers
Jin, Lei,Zhao, Shuai,Chen, Xin
, (2018)
A practical synthesis of both enantiomers of unnatural phenylalanine derivatives by using two pseudoenantiomeric phase transfer catalysts is described. Through asymmetric α-alkylation of glycine Schiff base with substituted benzyl bromides and 1-(bromomet
Anthranilic acid based CCK1 receptor antagonists: Preliminary investigation on their second "touch point"
Varnavas, Antonio,Lassiani, Lucia,Valenta, Valentina,Mennuni, Laura,Makovec, Francesco,Hadjipavlou-Litina, Dimitra
, p. 563 - 581 (2007/10/03)
In this phase of structure-affinity relationship study of VL-0395, a new anthranilic acid based CCK1 selective antagonist, we propose a series of unnatural aminoacidic derivatives. The result of this work is the identification of a new CCK ligand, which possesses an affinity (IC50 = 35 nm) one order of magnitude greater than the lead and, as a general rule, it points out how the hypothesized receptorial pocket which accommodates the Phe residue allows much more structural modification than that interacting with the N-terminal group. Hence, the modification of the C-terminal pharmacophoric group of our lead VL-0395 can not only enhance the affinity of anthranilic acid derivatives but can modulate the selectivity for one CCK receptor subtype or afford mixed antagonists.
